Number of the records: 1

Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water

SYSNO ASEP	0340611
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water
Author(s)	Gál, Miroslav (UFCH-W) Híveš, J. (SK) Sokolová, Romana (UFCH-W)_{RID, ORCID, SAI} Hromadová, Magdaléna (UFCH-W)_{RID, ORCID, SAI} Kolivoška, Viliam (UFCH-W)_{RID, ORCID} Pospíšil, Lubomír (UFCH-W)_{RID, ORCID}
Source Title	Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765 Roč. 74, 11-12 (2009), s. 1571-1581
Number of pages	11 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	electrochemistry ; electrochemical characteristics ; aromatic nitro-compounds
Subject RIV	CG - Electrochemistry
R&D Projects	GP203/09/P502 GA ČR - Czech Science Foundation (CSF)
	GA203/09/0705 GA ČR - Czech Science Foundation (CSF)
	LC510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC 140 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40400503 - UFCH-W (2005-2011)
UT WOS	000274667900001
DOI	10.1135/cccc2009118
Annotation	Electrochemical transfer of the first electron to cytotoxic radiosensitizer etanidazole (ETN) and ETN radical anion formation in the alkaline buffered aqueous solution were studied by means of electrochemical impedance spectroscopy (EIS). The heterogeneous electron transfer rate constant for the first reduction of ETN (radical anion production), k(0), was calculated. The value of k(0) from EIS measurements and the previously obtained value of so-called E-7(1) potential indicate that ETN, compared with other possible chemical radiosensitizers, requires lower energy to accept the first electron during the metabolic pathway. However, the necessity of the alkaline pH may decrease the ability of ETN to act as hypoxic radiosensitizer in the human body.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2010

Number of the records: 1