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The effect of laparotomy on hydroxyl radicals, singlet oxygen and antioxidants measured by EPR method in the tails of rats
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SYSNO ASEP 0340387 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The effect of laparotomy on hydroxyl radicals, singlet oxygen and antioxidants measured by EPR method in the tails of rats Author(s) Fricová, J. (CZ)
Stopka, Pavel (UACH-T) SAI
Křížová, Jana (UACH-T) SAI
Yamamotová, A. (CZ)
Rokyta, R. (CZ)Source Title Neuroendocrinology Letters - ISSN 0172-780X
Roč. 30, č. 3 (2009), s. 373-376Number of pages 4 s. Language eng - English Country SE - Sweden Keywords EPR-direct measurement in anesthetized rats ; laparotomy ; visceral pain Subject RIV ED - Physiology CEZ AV0Z40320502 - UACH-T (2005-2011) UT WOS 000272199300014 Annotation The aim of the study was to demonstrate that direct measurement of hydroxyl radicals and singlet oxygen in the tail of living rats is possible. The basic level of hydroxyl radicals and singlet oxygen were measured and the effects of antioxidants on their levels were studied in the tail of living anaesthetized rats after acute postoperative pain. Laparotomy was performed as the source of acute abdominal pain. After closure of the abdominal cavity, the animals began to awaken within 30-60 minutes. They were left to recover for 2-3 hours; then they were reanesthetized and the effect of antioxidants was measured on the numbers of hydroxyl radicals and singlet oxygen via blood in the tail. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2010
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