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Handbook of the Neuroscience of Aging
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SYSNO ASEP 0340083 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Aging: Extracellular Space Author(s) Syková, Eva (UEM-P) RID Source Title Handbook of the Neuroscience of Aging. - New York : Academic Press, 2009 / Hof P. R. - ISBN 978-0-12-374898-0 Pages s. 19-26 Number of pages 8 s. Number of copy 500 Number of pages 740 Language eng - English Country US - United States Keywords Alzheimer's ; Dementia ; Parkinson's Subject RIV FH - Neurology CEZ AV0Z50390703 - UEM-P (2007-2013) Annotation Aging, as well as many neurodegenerative diseases, is accompanied by serious cognitive deficits, particularly impaired learning and memory loss. Cognitive decline in old age has been linked to changes in brain anatomy, morphology, volume, and functional deficits. Nervous tissue, particularly in the hippocampus and cortex, is subject to various degenerative processes, including a decrease in the number and efficacy of synapses, neuronal loss, astrogliosis, and changes in extracellular matrix proteins. These and other changes not only affect the efficacy of signal transmission at synapses, but could also affect extrasynaptic (“volume”) transmission, mediated by the diffusion of transmitters Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
Number of the records: 1