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Maternal diabetes alters transcriptional programs in the developing embryo
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SYSNO ASEP 0339735 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Maternal diabetes alters transcriptional programs in the developing embryo Author(s) Pavlínková, Gabriela (BTO-N) RID, ORCID
Salbaum, M. (US)
Kappen, C. (US)Source Title BMC Genomics. - : BioMed Central - ISSN 1471-2164
Roč. 10, č. 274 (2009), s. 1-12Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords Diabetic embryopathy ; microarray ; hypoxia Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000268753700004 DOI 10.1186/1471-2164-10-274 Annotation Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We here report results from gene expression profiling of exposed embryos from a mouse diabetes model. In comparison to normal embryos at mid-gestation, we find significantly altered gene expression levels in diabetes-exposed embryos. Over 30% of the genes we have identified encode transcription factors and chromatin modifying proteins or components of signaling pathways that impinge on transcription. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2010
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