Number of the records: 1

Xanomeline binding to and activation of muscarinic receptors

SYSNO ASEP	0339422
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Xanomeline binding to and activation of muscarinic receptors
Author(s)	Jakubík, Jan (FGU-C)_{RID, ORCID} Machová, Eva (FGU-C) El-Fakahany, E. E. (US) Doležal, Vladimír (FGU-C)_{RID, ORCID}
Source Title	New trends in Alzheimer and Parkinson Related Disorders: ADPD 2009. - Pianoro : Medimond, 2009 / Fisher Abraham ; Hanin Israel - ISBN 978-88-7587-528-2
Pages	s. 145-148
Number of pages	4 s.
Action	International Conference Alzheimer´s diseases/Parkinson´s diseases /9./
Event date	11.05.2009-15.05.2009
VEvent location	Praha
Country	CZ - Czech Republic
Event type	WRD
Language	eng - English
Country	IT - Italy
Keywords	xanomeline ; muscarinic receptors ; signal transduction
Subject RIV	FH - Neurology
R&D Projects	IAA500110703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA305/09/0681 GA ČR - Czech Science Foundation (CSF)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
Annotation	Xanomeline binds reversibly to orthosteric binding site and irreversibly to another site of all subtypes of muscarinic receptors. In acute functional assays stimulates only M1/M4 subtypes. We demonstrated that irreversibly bound xanomeline also stimulates M2 receptors in cerebral cortex tissue
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1