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Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors

SYSNO ASEP	0339074
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors
Author(s)	Jakubík, Jan (FGU-C)_{RID, ORCID} Randáková, Alena (FGU-C)_{RID, ORCID} El-Fakahany, E. E. (US) Doležal, Vladimír (FGU-C)_{RID, ORCID}
Source Title	B M C Pharmacology - ISSN 1471-2210 Roč. 9, č. 15 (2009), s. 1-20
Number of pages	20 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	muscarinic receptors ; allosteric modulation ; rapacuronium
Subject RIV	ED - Physiology
R&D Projects	GA305/09/0681 GA ČR - Czech Science Foundation (CSF)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA500110703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
DOI	10.1186/1471-2210-9-15
Annotation	Albeit rapacuronium decreases affinity of acetylcholine under equilibrium conditions it accelerates acetylcholine binding. This results in potentiation of receptor activation by acetylcholine at low concentrations of rapacuronium. These observations highlight the necessity of performing functional tests under non-equilibrium conditions that resemble physiological conditions
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1