Number of the records: 1

Peroxidative damage of mitochondrial respiration is substrate-dependent

SYSNO ASEP	0338968
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Peroxidative damage of mitochondrial respiration is substrate-dependent
Author(s)	Endlicher, R. (CZ) Křiváková, P. (CZ) Rauchová, Hana (FGU-C)_{RID, ORCID} Nůsková, Hana (FGU-C)_{RID, ORCID} Červinková, Z. (CZ) Drahota, Zdeněk (FGU-C)_{RID, ORCID}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 58, č. 5 (2009), s. 685-692
Number of pages	8 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	mitochondrial enzymes ; peroxidative damage ; tert-butyl hydroperoxide
Subject RIV	CE - Biochemistry
R&D Projects	GA303/06/1261 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000272080200009
Annotation	The concentration-dependence of tert-butyl hydroperoxide (BHP) inhibitory effect on oxygen consumption in isolated rat liver mitochondria was measured in the presence of various respiratory substrates. Strong inhibitory effect at low concentrations of BHP (15-30 µM) was found for oxoglutarate and palmitoyl carnitine oxidation. Our data indicate that beside peroxidative damage of complex I also various mitochondrial NADH-dependent dehydrogenases are inhibited but to a different extent and with different kinetics. Our data also show that succinate could be an important nutritional substrate protecting hepatocytes during peroxidative damage
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1