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Nanotechnology for treatment of stroke and spinal cord injury
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SYSNO ASEP 0338739 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nanotechnology for treatment of stroke and spinal cord injury Author(s) Kubinová, Šárka (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RIDNumber of authors 2 Source Title Nanomedicine. - : Future Medicine - ISSN 1743-5889
Roč. 5, č. 1 (2010), s. 99-108Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords cell therapy ; contrast agents ; magnetic resonance Subject RIV FH - Neurology R&D Projects LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA500390902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN201110651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200520804 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000273674900015 DOI 10.2217/NNM.09.93 Annotation Stem cells have been shown to selectively target injured brain and spinal cord tissue and improve functional recovery. To allow cell detection, superparamagnetic iron oxide nanoparticles can be used to label transplanted cells. Magnetic resonance imaging is then a suitable method for the in vivo tracking of grafted cells in the host organism. CNS, and particularly spinal cord, injury is accompanied by tissue damage and the formation of physical and biochemical barriers that prevent axons from regenerating. One aspect of nanomedicine is the development of biologically compatible nanofiber scaffolds that mimic the structure of the extracellular matrix and can serve as a permissive bridge for axonal regeneration or as a drug delivery system. The incorporation of biologically active epitopes and/or the utilization of these scaffolds as stem cell carriers may further enhance their therapeutic efficacy. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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