Number of the records: 1

Ovarian hyperstimulation syndrome biomarker(s) search in human follicular fluid

SYSNO ASEP	0338300
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Ovarian hyperstimulation syndrome biomarker(s) search in human follicular fluid
Author(s)	Jarkovská, Karla (UZFG-Y)_RID Martinková, Jiřina (UZFG-Y) Skalníková, Helena (UZFG-Y)_{RID, ORCID} Hrabáková, Rita (UZFG-Y)_{RID, ORCID} Halada, Petr (MBU-M)_{RID, ORCID} Kavan, Daniel (MBU-M)_{RID, ORCID} Rezábek, K. (CZ) Gadher, S. J. (CH) Kovářová, Hana (UZFG-Y)_{RID, ORCID}
Source Title	3rd Central and Eastern Proteomics Conference, 2009. - Budapest : Hungarian proteomic society, 2009 - ISBN 978-963-9319-99-8
Pages	s. 47-47
Number of pages	1 s.
Action	3rd Central and Eastern European Proteomics Conference
Event date	06.10.2009-09.10.2009
VEvent location	Budapešť
Country	HU - Hungary
Event type	EUR
Language	eng - English
Country	HU - Hungary
Keywords	Ovarian hyperstimulation syndrom ; Follicular fluid ; Biomarkers
Subject RIV	FK - Gynaecology, Childbirth
R&D Projects	1QS500450568 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z50450515 - UZFG-Y (2005-2011)
Annotation	Ovarian hyperstimulation syndrome (OHSS) is a serious complication of in vitro fertilisation therapy using hormonal stimulation of ovaries. Current diagnosis is not sufficient and could be significantly improved if a protein biomarker(s) could be identified in patient follicular fluid (HFF). In search for new potential diagnostic and prognostic biomarker(s) of OHSS we have used a combination of immunoaffinity depletion, 2-D LC and 2-DE to obtain 2D protein profiles of HFF from OHSS positive and OHSS negative women. The protein maps were evaluated using software tools and protein spots or bands significantly increased or decreased in HFF of OHSS positive and OHSS negative women were identified using MS. In total, we identified 20 proteins and 3 of them were shared between two different 2D technologies. Most of the identified proteins belong to different functional groups including the complement cascade, transport, blood coagulation, acute phase response and inflammation.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2010

Number of the records: 1