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In-depth study of the human follicular fluid for a diagnostic / prognostic marker of ovarian hyperstimulation syndrome

SYSNO ASEP	0338289
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	In-depth study of the human follicular fluid for a diagnostic / prognostic marker of ovarian hyperstimulation syndrome
Title	Studie o folikulární tekutině, jako marktu hyperstimulačního syndromu lidských vaječníků
Author(s)	Jarkovská, Karla (UZFG-Y)_RID Martinková, Jiřina (UZFG-Y) Skalníková, Helena (UZFG-Y)_{RID, ORCID} Hrabáková, Rita (UZFG-Y)_{RID, ORCID} Halada, Petr (MBU-M)_{RID, ORCID} Kavan, Daniel (MBU-M)_{RID, ORCID} Gadher, S. J. (CH) Kovářová, Hana (UZFG-Y)_{RID, ORCID}
Source Title	3rd EuPA Congress Clinical Proteomics. - Veszprem : OOK-PRESS Kft, 2009 / Marko - Varga Gyorgy ; Laurell Thomas - ISBN 978-963-86156-4-0
Pages	s. 243-245
Number of pages	3 s.
Action	3rd EuPA Congress Clinical Proteomics
Event date	14.06.2009-17.06.2009
VEvent location	Stockholm
Country	CH - Switzerland
Event type	EUR
Language	eng - English
Country	HU - Hungary
Keywords	human folicular fluid ; ovarian hyperstimulation syndrome ; gel elctrophoresis
Subject RIV	FK - Gynaecology, Childbirth
R&D Projects	1QS500450568 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LC07017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z50450515 - UZFG-Y (2005-2011)
Annotation	Ovarian hyperstimulation syndrome (OHSS) is a serious complication of in vitro fertilisation therapy using hormonal stimulation of ovaries. Current diagnosis is not sufficient and could be significantly improved if a protein biomarker(s) could be identified in patient follicular fluid (HFF). In search for new potential diagnostic and prognostic biomarker(s) of OHSS we have used a combination of immunoaffinity depletion, 2-D LC and 2-DE to obtain 2D protein profiles of HFF from OHSS positive and OHSS negative women. The protein maps were evaluated using software tools and protein spots or bands significantly increased or decreased in HFF of OHSS positive and OHSS negative women were identified using MS. In total, we identified 20 proteins and 3 of them were shared between two different 2D technologies. Most of the identified proteins belong to different functional groups including the complement cascade, transport, blood coagulation, acute phase response and inflammation.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2010

Number of the records: 1