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Base excision repair, aging and health span
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SYSNO ASEP 0338211 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Base excision repair, aging and health span Title Bazové excizní opravny mechanizmu, stárnutí a délka života Author(s) Xu, G. (US)
Herzig, M. (US)
Rotrekl, Vladimír (UEM-P)
Walter, Ch. A. (US)Number of authors 4 Source Title Mechanisms of Ageing and Development. - : Elsevier - ISSN 0047-6374
Roč. 129, 7-8 (2008), s. 366-382Number of pages 15 s. Language eng - English Country IE - Ireland Keywords base excision repair ; aging ; DNA damage Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000257816100003 DOI 10.1016/j.mad.2008.03.001 Annotation The BER pathway ameliorates a large number of DNA lesions that arise spontaneously. BER activity decreases with age in multiple tissues. The specific BER protein that appears to limit activity varies among tissues. DNA polymerase-beta is reduced in brain from aged mice and rats while AP endonuclease is reduced in spermatogenic cells obtained from old mice. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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