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Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis
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SYSNO ASEP 0338123 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis Title Interakce mezi bZIP proteiny Atf3 a Jun blokuje obměnu epiteliálních buněk během metamorfózy u mouchy Drosophila Author(s) Sekyrová, Petra (BC-A)
Bohmann, D. (US)
Jindra, Marek (BC-A) RID, ORCID
Uhlířová, M. (DE)Number of authors 4 Source Title Development. - : Company of Biologists - ISSN 0950-1991
Roč. 137, č. 1 (2010), s. 141-150Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords epithelial cell replacement ; cell adhesion ; epidermis Subject RIV EA - Cell Biology R&D Projects 2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000272977200018 DOI 10.1242/dev.037861 Annotation Animal development involves movements and fusions of epithelia. During metamorphosis of Drosophila, the precursor cells of abdominal epidermis (histoblasts) divide and migrate while replacing larval epidermal cells (LECs), which must depart from the epithelium to allow histoblast fusion and formation of the adult epidermis. Regulation of this morphogenetic cell replacement is unclear. We have found that temporally misregulated activity of the transcription factor Atf3 prevents LEC extrusion by interfering with the Rho signaling, leading to increased adhesiveness of LECs that consequently obstruct the closure of the adult abdominal epithelium. To elicit this effect, Atf3 requires its binding partner Jun. Although dimerization between the two important regulatory bZIP proteins has been well-established in mammalian cell lines, our data for the first time demonstrate a developmental function for the Jun-Atf3 complex in vivo. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2010
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