Number of the records: 1
Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria
- 1.
SYSNO ASEP 0338071 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Diabetes and thyroid hormones affect connexin-43 and PKC-ε expression in rat heart atria Title Ovlivnění exprese konexinu 43 a PKC-ε v atriích potkana diabetem a tyroidními hormony Author(s) Mitašíková, M. (SK)
Lin, H. (JP)
Soukup, Tomáš (FGU-C) RID
Imanaga, I. (JP)
Tribulová, N. (SK)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 58, č. 2 (2009), s. 211-217Number of pages 7 s. Language eng - English Country CZ - Czech Republic Keywords diabetes ; triiodothyronine ; atrial fibrillation Subject RIV ED - Physiology R&D Projects LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA304/05/0327 GA ČR - Czech Science Foundation (CSF) GA304/08/0256 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000265853100007 Annotation Cx43 expression was significantly increased after the treatment with T3 and in the acute diabetes. Both in diabetes and after T3 treatment the phosphorylation ofCx43 isoforms was markedly suppressed compared to the nondiabetic and T3-untreated controls. Such a down-regulation was less pronounced in diabetic rats after the T3-treatment. The expression of atrial PKC-ε was increased in diabetic rats. This increase was suppressed after T3 administration and the expression was decreased in T3-treated non-diabetic rats. We suggest that the reduced Cx43 phosphorylation in diabetic and hyperthyroid rats can deteriorate a cell-to-cell coupling and consequently facilitate a development of atrial tachyarrhythmia in diabetic or hyperthyroid animals Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
Number of the records: 1