Number of the records: 1

Effect of protein kinase C and protein kinase A inhibitors on contraction of isolated femoral arteries of SHR and Wistar rats

SYSNO ASEP	0338042
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Effect of protein kinase C and protein kinase A inhibitors on contraction of isolated femoral arteries of SHR and Wistar rats
Title	Účinek inhibitorů protein kináz C a A na kontrakci izolovaných femorálních artérií SHR a Wistar potkanů
Author(s)	Bal, Manjot Singh (FGU-C) Paulis, Ĺudovít (FGU-C) Zicha, Josef (FGU-C)_{RID, ORCID, SAI} Kuneš, Jaroslav (FGU-C)_{RID, ORCID}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 58, č. 6 (2009), s. 793-798
Number of pages	6 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	femoral artery ; calcium ; myograph
Subject RIV	ED - Physiology
R&D Projects	IAA500110902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000273296600003
Annotation	Alterations of calcium handling and other second messenger cascades including protein kinase C (PKC) and A (PKA) were suggested to be responsible for abnormal vascular function in spontaneously hypertensive rats (SHR). Vasoconstriction elicited by adrenergic stimulation is more dependent on extracellular calcium influx in SHR compared to Wistar rats. The activation of PKA contributes to this calcium-dependent vasoconstriction in SHR but not in Wistar. On the other hand, PKC activation seems to play a less important role in vasoconstriction in SHR than in Wistar rats
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1