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Impaired control of L-type voltage-dependent calcium channels in experimental hypertension

SYSNO ASEP	0338019
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Impaired control of L-type voltage-dependent calcium channels in experimental hypertension
Title	Změněná kontrola napěťově řízených vápníkových kanálů L typu u experimentální hypertenze
Author(s)	Pintérová, Mária (FGU-C) Líšková, Silvia (FGU-C) Dobešová, Zdenka (FGU-C) Behuliak, M. (SK) Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 58, Suppl.2 (2009), S43-S54
Number of pages	12 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	calcium-activated K+ and Cl- channels ; vasoactive systems ; EDCF
Subject RIV	ED - Physiology
R&D Projects	GA305/08/0139 GA ČR - Czech Science Foundation (CSF)
	GA305/09/0336 GA ČR - Czech Science Foundation (CSF)
	IAA500110902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000273537200005
Annotation	Most of the forms of experimental hypertension are associated with sympathetic hyperactivity and endothelial dysfunction. It is evident that nitric oxide and norepinephrine are antagonists in the control of calcium influx through L-type voltage-dependent calcium channels (L-VDCC). Their effects on L-VDCC are mediated by cGMP and cAMP, respectively. Rats with genetic or salt hypertension are characterized by a relative (but not absolute) NO deficiency compared to the absolute enhancement of sympathetic vasoconstriction. This dysbalance of vasoconstrictor and vasodilator systems in hypertensive animals is reflected by greater calcium influx through L-VDCC susceptible to the inhibition by nifedipine
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1