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Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole
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SYSNO ASEP 0337712 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole Author(s) Charbonnel, N. (FR)
Bryja, Josef (UBO-W) RID, SAI, ORCID
Galan, M. (FR)
Deter, J. (FR)
Tollenaere, C. (FR)
Chaval, Y. (FR)
Morand, S. (FR)
Cosson, J.-F. (FR)Number of authors 8 Source Title Evolutionary Applications. - : Wiley - ISSN 1752-4571
Roč. 3, č. 3 (2010), s. 279-290Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords abundance cycles ; Dqa and Drb ; immunocompetence handicap ; Mhc class II genes ; parasite-mediated balancing selection ; sexual selection Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000276790700004 EID SCOPUS 77954309014 DOI https://doi.org/10.1111/j.1752-4571.2009.00108.x Annotation Heterogeneities in immune responsiveness may affect key epidemiological parameters and the dynamics of pathogens. We analysed the influence of Major histocompatibility complex (Mhc) genes and epigamic traits on the response to phytohaemagglutinin in males from cyclic populations of the montane water vole (Arvicola scherman). We found a negative relationship between Mhc hetetozygosity and response to phytohaemagglutinin, mediated by a specific Mhc genotype (Arte-Dqa-05 homozygous genotype being a ‘good’ Mhc variant in terms of immunogenetic quality). The development of the scent glands seems to be an honest signal for mate choice as it is negatively correlated with helminth load. The ‘good gene’ hypothesis was not validated as Arte-Dqa-05 homozygous males did not exhibit larger glands. Besides, the negative relationship observed between the size of these glands and the response to phytohaemagglutinin, mainly for Mhc homozygotes, corroborates the immunocompetence handicap hypothesis. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2011
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