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Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole

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    SYSNO ASEP0337712
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleNegative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole
    Author(s) Charbonnel, N. (FR)
    Bryja, Josef (UBO-W) RID, SAI, ORCID
    Galan, M. (FR)
    Deter, J. (FR)
    Tollenaere, C. (FR)
    Chaval, Y. (FR)
    Morand, S. (FR)
    Cosson, J.-F. (FR)
    Number of authors8
    Source TitleEvolutionary Applications - ISSN 1752-4571
    Roč. 3, č. 3 (2010), s. 279-290
    Number of pages12 s.
    Languageeng - English
    CountryGB - United Kingdom
    Keywordsabundance cycles ; Dqa and Drb ; immunocompetence handicap ; Mhc class II genes ; parasite-mediated balancing selection ; sexual selection
    Subject RIVEB - Genetics ; Molecular Biology
    CEZAV0Z60930519 - UBO-W (2005-2011)
    UT WOS000276790700004
    EID SCOPUS77954309014
    DOI10.1111/j.1752-4571.2009.00108.x
    AnnotationHeterogeneities in immune responsiveness may affect key epidemiological parameters and the dynamics of pathogens. We analysed the influence of Major histocompatibility complex (Mhc) genes and epigamic traits on the response to phytohaemagglutinin in males from cyclic populations of the montane water vole (Arvicola scherman). We found a negative relationship between Mhc hetetozygosity and response to phytohaemagglutinin, mediated by a specific Mhc genotype (Arte-Dqa-05 homozygous genotype being a ‘good’ Mhc variant in terms of immunogenetic quality). The development of the scent glands seems to be an honest signal for mate choice as it is negatively correlated with helminth load. The ‘good gene’ hypothesis was not validated as Arte-Dqa-05 homozygous males did not exhibit larger glands. Besides, the negative relationship observed between the size of these glands and the response to phytohaemagglutinin, mainly for Mhc homozygotes, corroborates the immunocompetence handicap hypothesis.
    WorkplaceInstitute of Vertebrate Biology
    ContactHana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
    Year of Publishing2011
Number of the records: 1