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Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole

SYSNO ASEP	0337712
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Negative relationships between cellular immune response, Mhc class II heterozygosity and secondary sexual trait in the montane water vole
Author(s)	Charbonnel, N. (FR) Bryja, Josef (UBO-W)_{RID, SAI, ORCID} Galan, M. (FR) Deter, J. (FR) Tollenaere, C. (FR) Chaval, Y. (FR) Morand, S. (FR) Cosson, J.-F. (FR)
Number of authors	8
Source Title	Evolutionary Applications. - : Wiley - ISSN 1752-4571 Roč. 3, č. 3 (2010), s. 279-290
Number of pages	12 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	abundance cycles ; Dqa and Drb ; immunocompetence handicap ; Mhc class II genes ; parasite-mediated balancing selection ; sexual selection
Subject RIV	EB - Genetics ; Molecular Biology
CEZ	AV0Z60930519 - UBO-W (2005-2011)
UT WOS	000276790700004
EID SCOPUS	77954309014
DOI	10.1111/j.1752-4571.2009.00108.x
Annotation	Heterogeneities in immune responsiveness may affect key epidemiological parameters and the dynamics of pathogens. We analysed the influence of Major histocompatibility complex (Mhc) genes and epigamic traits on the response to phytohaemagglutinin in males from cyclic populations of the montane water vole (Arvicola scherman). We found a negative relationship between Mhc hetetozygosity and response to phytohaemagglutinin, mediated by a specific Mhc genotype (Arte-Dqa-05 homozygous genotype being a ‘good’ Mhc variant in terms of immunogenetic quality). The development of the scent glands seems to be an honest signal for mate choice as it is negatively correlated with helminth load. The ‘good gene’ hypothesis was not validated as Arte-Dqa-05 homozygous males did not exhibit larger glands. Besides, the negative relationship observed between the size of these glands and the response to phytohaemagglutinin, mainly for Mhc homozygotes, corroborates the immunocompetence handicap hypothesis.
Workplace	Institute of Vertebrate Biology
Contact	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Year of Publishing	2011

Number of the records: 1