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Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension
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SYSNO ASEP 0337037 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension Title Vliv podání pertusis toxinu na vývoj hypertenze vyvolané L-NAME Author(s) Zicha, Josef (FGU-C) RID, ORCID, SAI
Kuneš, Jaroslav (FGU-C) RID, ORCID
Vranková, S. (SK)
Jendeková, L. (SK)
Dobešová, Zdenka (FGU-C)
Pintérová, Mária (FGU-C)
Pecháňová, Olga (FGU-C)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 58, č. 5 (2009), s. 751-755Number of pages 5 s. Language eng - English Country CZ - Czech Republic Keywords sympathetic nervous system ; nitric oxide ; inhibitory G proteins Subject RIV ED - Physiology R&D Projects GA305/08/0139 GA ČR - Czech Science Foundation (CSF) 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000272080200017 Annotation High blood pressure (BP) of rats with hypertension induced by NO synthase inhibitor L-NAME is maintained not only by the absence of nitric oxide (NO)-dependent vasodilatation but also by the enhancement of both sympathetic and angiotensin II-dependent vasoconstriction. The impairment of sympathetic vasoconstriction due to PTX-induced inhibitory G protein inactivation prevents the full development of NO-deficient hypertension because BP of PTX-treated rats subjected to chronic L-NAME administration did not reach hypertensive values Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
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