Number of the records: 1

Current and Novel Inhibitors of HIV Protease

SYSNO ASEP	0336551
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Current and Novel Inhibitors of HIV Protease
Author(s)	Pokorná, Jana (UOCHB-X)_RID Machala, L. (CZ) Řezáčová, Pavlína (UOCHB-X)_{RID, ORCID} Konvalinka, Jan (UOCHB-X)_{RID, ORCID}
Number of authors	4
Source Title	Viruses. - : MDPI Roč. 1, č. 3 (2009), s. 1209-1239
Number of pages	31 s.
Language	eng - English
Country	CH - Switzerland
Keywords	HIV protease ; protease inhibitor ; HAART
Subject RIV	CE - Biochemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000280413200044
DOI	10.3390/v1031209
Annotation	This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1