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In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis
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SYSNO ASEP 0335925 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis Author(s) Landa, Přemysl (UEB-Q) RID, ORCID
Kokoška, L. (CZ)
Přibylová, Marie (UEB-Q)
Vaněk, Tomáš (UEB-Q) RID, ORCID
Maršík, Petr (UEB-Q) RID, ORCIDSource Title Archives of Pharmacal Research - ISSN 0253-6269
Roč. 32, č. 1 (2009), s. 75-78Number of pages 4 s. Language eng - English Country KR - Korea, Republic of Keywords Carvacrol ; Cyclooxygenase ; Prostaglandin Subject RIV GM - Food Processing R&D Projects GA525/08/1179 GA ČR - Czech Science Foundation (CSF) 1P04OC926.001 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000262851700010 DOI 10.1007/s12272-009-1120-6 Annotation Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2010
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