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Selective Cyclin-Dependent Kinase Inhibitors Discriminating between Cell Cycle and Transcriptional Kinases Future Reality or Utopia?

SYSNO ASEP	0335863
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Selective Cyclin-Dependent Kinase Inhibitors Discriminating between Cell Cycle and Transcriptional Kinases Future Reality or Utopia?
Title	Selektivní inhibitory CDK rozlišující kinasy regulující buněčný cyklus a transkripci: Realita nebo utopie?
Author(s)	Wesierska-Gadek, J. (AT) Kryštof, Vladimír (UEB-Q)_{RID, ORCID}
Source Title	New York Academy of Sciences. Annals - ISSN 0077-8923 Roč. 1171, - (2009), s. 228-241
Number of pages	14 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	cell cycle ; CYC202 ; cyclin-dependent kinase
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA204/08/0511 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000269657300030
DOI	10.1111/j.1749-6632.2009.04726.x
Annotation	Progression of the cell cycle is controlled by activating and inhibiting cellular factors. The delicate balance between these positive- and negative-acting regulators warrants proper cell cycle progression in normal cells and facilitates cellular response to a variety of stress stimuli. The increased activity of the positive regulators of the cell cycle in cancer cells is frequently accompanied by the loss or inactivation of the inhibitors of cyclin-dependent kinases (CDKs). The supplementation of the cellular CDK inhibitors by the pharmacological counterparts is a very promising therapeutic option. The generated pharmacological inhibitors of CDKs belong to different classes of compounds and display various CDK inhibitory features. In this article the action and specificity of CDK inhibitor roscovitine, belonging to the group of purine analogues, is reviewed and the rationale for dissecting the inhibitory action on cell cycle and transcriptional CDKs is discussed.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2010

Number of the records: 1