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n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet

SYSNO ASEP	0335665
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet
Title	n-3 mastné kyseliny a roziglitazon zlepšují citlivost k inzulínu přes pomocný stimulační efekt na syntézu glykogenu ve svalu u myší krmených vysokotukovou dietou
Author(s)	Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI} Jeleník, Tomáš (FGU-C) Jílková, Zuzana (FGU-C) Flachs, Pavel (FGU-C)_RID Rossmeisl, Martin (FGU-C)_{RID, ORCID} Hensler, Michal (FGU-C) Kazdová, L. (CZ) Ogston, N. (GB) Baranowski, M. (PL) Gorski, J. (PL) Janovská, Petra (FGU-C)_{RID, ORCID} Kůs, Vladimír (FGU-C) Polák, J. (CR) Mohamed-Ali, V. (GB) Burcelin, R. (FR) Cinti, S. (IT) Bryhn, M. (NO) Kopecký, Jan (FGU-C)_{RID, ORCID}
Source Title	Diabetologia - ISSN 0012-186X Roč. 52, č. 5 (2009), s. 941-951
Number of pages	11 s.
Language	eng - English
Country	DE - Germany
Keywords	fish oil ; rosiglitazone ; obesity
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
R&D Projects	GA303/08/0664 GA ČR - Czech Science Foundation (CSF)
	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC08007 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000264884100027
DOI	10.1007/s00125-009-1305-z
Annotation	DHA/EPA and rosiglitazone exerted additive effects in prevention of obesity, adipocyte hypertrophy, low–grade adipose tissue inflammation, dyslipidaemia and insulin resistance, while inducing adiponectin, suppressing hepatic lipogenesis and decreasing muscle ceramide concentration in mice fed high-fat diet. The improvement in glucose tolerance reflected a synergistic stimulatory effect of the combined treatment on muscle glycogen synthesis and its sensitivity to insulin. The combination treatment also reversed dietary obesity, dislipedemia and IGT
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1