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Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water
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SYSNO ASEP 0335375 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Author(s) Gál, Miroslav (UFCH-W)
Hromadová, Magdaléna (UFCH-W) RID, ORCID, SAI
Pospíšil, Lubomír (UFCH-W) RID, ORCID
Híveš, J. (SK)
Sokolová, Romana (UFCH-W) RID, ORCID, SAI
Kolivoška, Viliam (UFCH-W) RID, ORCID
Kocábová, Jana (UFCH-W) RIDSource Title Bioelectrochemistry. - : Elsevier - ISSN 1567-5394
Roč. 78, č. 2 (2010), s. 118-123Number of pages 6 s. Language eng - English Country CH - Switzerland Keywords etanidazole ; radiosensitizer ; electron transfer ; voltammetry Subject RIV CG - Electrochemistry R&D Projects GP203/09/P502 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000277218900004 DOI 10.1016/j.bioelechem.2009.08.008 Annotation Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN − NO2 + e− right arrow over left arrow ETN − NO2•− was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2011
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