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Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet

SYSNO ASEP	0335324
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet
Title	Významná úloha jater u zvýšených hladin palmitoleátu v plazmě jako odpověď na roziglitazon u myší krmených vysokotukovou dietou
Author(s)	Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI} Staňková, B. (CZ) Tvrzická, E. (CZ) Hensler, Michal (FGU-C) Jeleník, Tomáš (FGU-C) Rossmeisl, Martin (FGU-C)_{RID, ORCID} Flachs, Pavel (FGU-C)_RID Kopecký, Jan (FGU-C)_{RID, ORCID}
Source Title	Journal of Physiology and Pharmacology. - : Polskie Towarzystwo Fizjologiczne - ISSN 0867-5910 Roč. 60, č. 4 (2009), s. 125-140
Number of pages	6 s.
Language	eng - English
Country	PL - Poland
Keywords	palmitoleic acid ; stearoyl-CoA desaturase ; thiazolidinediones
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
R&D Projects	GA303/08/0664 GA ČR - Czech Science Foundation (CSF)
	GD305/08/H037 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000273377500017
Annotation	Aim of this study was to characterise contribution of liver to changes of plasma lipid profile in response to an 8-week-treatment by rosiglitazone in the cHF diet-fed mice. Increased palmitoleate synthesis and complex changes of lipid composition in the liver in response to the rosiglitazone treatment could represent the main mechanism underlying the changes in plasma lipid profile, which could be beneficial for the insulin-sensitizing effect of TZDs
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1