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Morphological changes in human neural cells followign tick-borne encephalitis infection
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SYSNO ASEP 0335287 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Morphological changes in human neural cells followign tick-borne encephalitis infection Author(s) Růžek, Daniel (BC-A) RID, ORCID
Vancová, Marie (BC-A) RID, ORCID
Tesařová, Martina (BC-A) ORCID
Ahantarig, A. (TH)
Kopecký, Jan (BC-A) RID
Grubhoffer, Libor (BC-A) RID, ORCIDSource Title Journal of General Virology. - : Microbiology Society - ISSN 0022-1317
Roč. 90, č. 7 (2009), s. 1649-1658Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords tick-borne encephalitis virus ; human neural cells ; central nervous system Subject RIV EE - Microbiology, Virology R&D Projects GA524/08/1509 GA ČR - Czech Science Foundation (CSF) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000267955900013 DOI 10.1099/vir.0.010058-0 Annotation Tick-borne encephalitis (TBE) is one of the leading and most dangerous human viral neuroinfections in Europe and north-eastern Asia. The clinical manifestations include asymptomatic infections, fevers and debilitating encephalitis that might progress into chronic disease or fatal infection. To understand TBE pathology further in host nervous systems, three human neural cell lines, neuroblastoma, medulloblastoma and glioblastoma, were infected with TBE virus (TBEV). The susceptibility and virus-mediated cytopathic effect, including ultrastructural and apoptotic changes of the cells, were examined. The neuropathological significance of the observations is discussed. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2010
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