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Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin
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SYSNO ASEP 0335110 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin Author(s) Kubíková, I. (CZ)
Konečná, H. (CZ)
Šedo, O. (CZ)
Zdráhal, Z. (CZ)
Řehulka, Pavel (UIACH-O)
Hříbková, H. (CZ)
Řehulková, Helena (UIACH-O)
Hampl, Aleš (UEM-P)
Chmelík, Josef (UIACH-O)
Dvořák, Petr (UEM-P)Number of authors 10 Source Title Cytotherapy. - : Elsevier - ISSN 1465-3249
Roč. 11, č. 3 (2009), s. 330-340Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords human embryonic stem cell ; hESC ; proteomic profiling Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40310501 - UIACH-O (2005-2011) AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000265581600010 DOI 10.1080/14653240802595531 Annotation Microvesicles (MVs) shed from the plasma membrane of eukaryotic cells including human embryonic stem cells (hESCs) contain proteins, lipids, and RNAs and serve as mediators of cell-to-cell communication. However, they may also contain immunogenic membrane domains or infectious particles acquired from xenogenic components of the culture milieu. Therefore, MVs represent a potential risk for the clinical application of cell therapy. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2010
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