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Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines

SYSNO ASEP	0335022
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines
Title	Rozdíly ve změnách exprese Mcl-1 indukované TRAILem u různých lidských epiteliálních buněk tlustého střeva
Author(s)	Vaculová, Alena (BFU-R)_{RID, ORCID} Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Zatloukalová, Jiřina (BFU-R) Kozubík, Alois (BFU-R)_{RID, ORCID}
Number of authors	4
Source Title	Experimental Cell Research. - : Elsevier - ISSN 0014-4827 Roč. 315, č. 19 (2009), s. 3259-3266
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	TRAIL ; Mcl-1 ; apoptosis
Subject RIV	BO - Biophysics
R&D Projects	GA524/07/1178 GA ČR - Czech Science Foundation (CSF)
	GA301/07/1557 GA ČR - Czech Science Foundation (CSF)
	1QS500040507 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000271698000004
DOI	10.1016/j.yexcr.2009.09.019
Annotation	We examined the changes of anti-apoptotic Mcl-1 protein level following TRAIL treatment in human epithelial cells representing different stages of colon carcinogenesis. While TRAIL was capable of triggering an anti-apoptotic signaling leading to significant early ERK-mediated transcriptional up-regulation of Mcl-1 in selected colon adenocarcinoma cell lines, none or very limited effects were demonstrated in cell lines derived from colon lymph node metastasis or fetal colon. We demonstrated an immediate impact of Mcl-1 protein level manipulations on the course of early acute apoptotic response of colon adenocarcinoma cells to TRAIL.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1