Number of the records: 1

CD8+ T-cells mediate immunopathology in tick-borne encephalitis

SYSNO ASEP	0334945
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	CD8+ T-cells mediate immunopathology in tick-borne encephalitis
Author(s)	Růžek, Daniel (BC-A)_{RID, ORCID} Salát, Jiří (BC-A)_{RID, ORCID} Palus, M. (CZ) Gritsun, T. S. (GB) Gould, E. A. (GB) Dyková, Iva (BC-A)_RID Skallová, Anna (BC-A) Jelínek, Jiří (BC-A) Kopecký, Jan (BC-A)_RID Grubhoffer, Libor (BC-A)_{RID, ORCID}
Source Title	Virology. - : Elsevier - ISSN 0042-6822 Roč. 384, č. 1 (2009), s. 1-6
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	tick-borne encephalitis ; immunopathology ; encephalitis
Subject RIV	EE - Microbiology, Virology
R&D Projects	LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA524/08/1509 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000263039200001
DOI	10.1016/j.virol.2008.11.023
Annotation	Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2010

Number of the records: 1