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The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans
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SYSNO ASEP 0334921 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans Title Jaderný receptor NHR-25 spolupracuje s Wnt/ .beta.-kateninovou asymetrickou dráhou v regulaci diferenciace T buňky u C. elegans Author(s) Hajdušková, Martina (BC-A)
Jindra, Marek (BC-A) RID, ORCID
Herman, M. A. (US)
Asahina, Masako (BC-A) RIDSource Title Journal of Cell Science. - : Company of Biologists - ISSN 0021-9533
Roč. 122, č. 17 (2009), s. 3051-3060Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords nuclear receptor ; Wnt/.beta.-catenin signaling ; Caenorhabditis elegans Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/07/0948 GA ČR - Czech Science Foundation (CSF) GD204/09/H058 GA ČR - Czech Science Foundation (CSF) 2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000269122000005 Annotation Asymmetric cell divisions produce cells with distinct developmental fates, thus allowing differentiation of various tissues. Caenorhabditis elegans is extensively used to study cell fate determination, since its development relies heavily on asymmetric cell divisions. Differentiation of the epidermal cell T depends on its proper polarity that is established by the Wnt/.beta.-catenin asymmetry pathway. We show that the asymmetry of T cell division requires NHR-25, an evolutionarily conserved nuclear receptor. NHR-25 ensures the neural fate of the T cell lineage in cooperation with the Wnt/.beta.-catenin signaling. Loss of NHR-25 enhances the impact of mutated effectors of this pathway, POP-1/TCF and SYS-1/.beta.-catenin, on the T cell polarity, while it suppresses the effect of the same mutations on asymmetric division of the somatic gonad precursor cells. Therefore, our findings define NHR-25 as a versatile modulator of Wnt/.beta.-catenin signaling to govern correct cell fate decision. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2010
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