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Evolution of the serum resistance-associated SRA gene in African trypanosomes
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SYSNO ASEP 0334919 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evolution of the serum resistance-associated SRA gene in African trypanosomes Title Evoluce genu asociovaného s sra u afrických trypanosom Author(s) Lai, D. H. (CN)
Wang, Q.P. (CN)
Lukeš, Julius (BC-A) RID, ORCID
Lun, Z.R. (CN)Source Title Chinese Science Bulletin - ISSN 1001-6538
Roč. 54, č. 7 (2009), s. 1275-1278Number of pages 4 s. Language eng - English Country CN - China Keywords SRA ; SRAbc ; evolution ; African trypanosomes Subject RIV EB - Genetics ; Molecular Biology R&D Projects 2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000264842600022 Annotation Serum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicated that they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the "donor VSG", which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2010
Number of the records: 1