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Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks
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SYSNO ASEP 0334910 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks Author(s) Horká, Helena (BC-A) RID
Černá-Kýčková, Kateřina (BC-A)
Skallová, Anna (BC-A)
Kopecký, Jan (BC-A) RIDSource Title International Journal of Medical Microbiology. - : Elsevier - ISSN 1438-4221
Roč. 299, č. 5 (2009), s. 373-380Number of pages 8 s. Language eng - English Country DE - Germany Keywords Borrelia burgdorferi ; Ixodes ricinus ; saliva-activated transmission ; real-time PCR Subject RIV EC - Immunology R&D Projects IAA600960811 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000267688600007 Annotation The influence of the feeding of uninfected Ixodes ricinus nymphs on the proliferation and distribution of Borrelia burgdorferi spirochetes was compared with the effect of coinoculated saliva or salivary gland extract (SGE). SGE significantly increased spirochete numbers in the skin 4 and 6 dpi, but decreased bacterial load in the heart compared to control animals. The inoculation of tick saliva increased spirochete load in the urinary bladder 6 dpi, while the number of spirochetes in the heart declined. The nymph feeding raised spirochete load in the bladder 4 and 6 dpi. On day 6, the number of spirochetes in the heart was significantly lower than in controls. The prevalence of spirochetes in ticks infected by feeding on mice was 10× higher when the mice were infected with spirochetes and saliva or SGE, in comparison with spirochetes alone. The presence of SGE in the inoculum increased spirochete burden per tick from 0 to almost 28000. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2010
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