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Tick-borne encephalitis virus infection of cultured mouse macrophages

SYSNO ASEP	0334900
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Tick-borne encephalitis virus infection of cultured mouse macrophages
Author(s)	Ahantarig, A. (TH) Růžek, Daniel (BC-A)_{RID, ORCID} Vancová, Marie (BC-A)_{RID, ORCID} Janowitz, A. (GB) Šťastná, Hana (BC-A) Tesařová, Martina (BC-A)_ORCID Grubhoffer, Libor (BC-A)_{RID, ORCID}
Source Title	Intervirology - ISSN 0300-5526 Roč. 52, č. 5 (2009), s. 283-290
Number of pages	8 s.
Language	eng - English
Country	SZ - Swaziland
Keywords	tick-borne encephalitis ; macrophages ; electron microscopy
Subject RIV	GJ - Animal Vermins ; Diseases, Veterinary Medicine
R&D Projects	GA524/06/1479 GA ČR - Czech Science Foundation (CSF)
	LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000269788600008
DOI	10.1159/000235741
Annotation	The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratory mice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2010

Number of the records: 1