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Chemoenzymatic preparative separation of silybins A and B
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SYSNO ASEP 0334834 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chemoenzymatic preparative separation of silybins A and B Title Chemoenzymatická preparativní separace silybinů A a B Author(s) Křen, Vladimír (MBU-M) RID, ORCID
Gažák, Radek (MBU-M) RID, ORCID
Purchartová, Kateřina (MBU-M) RID
Marhol, Petr (MBU-M) RID
Biedermann, David (MBU-M) RID, ORCID
Sedmera, Petr (MBU-M)Source Title Journal of Molecular Catalysis B-Enzymatic. - : Elsevier - ISSN 1381-1177
Roč. 61, 3-4 (2009), s. 247-251Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords Silymarin ; Silibinin ; Silybin A Subject RIV CC - Organic Chemistry R&D Projects OC09045 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) KJB400200701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA303/08/0658 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000272064600022 DOI 10.1016/j.molcatb.2009.07.013 Annotation Robust and scalable chemoenzymatic procedure for obtaining gram amounts of pure silybin A and B within one week is described. It consists of the preparation of 23-O-B-pentaacetyl-galactopyranosides of silybin, their separation by silica gel chromatography, deprotection, and enzymatic sugar removal with B-galactosidase Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
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