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The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects

SYSNO ASEP	0334798
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects
Author(s)	Lorenz, N. (DE) Haarmann, T. (DE) Pažoutová, Sylvie (MBU-M) Jung, M. (DE) Tudzynski, P. (DE)
Source Title	Phytochemistry. - : Elsevier - ISSN 0031-9422 Roč. 70, 15-16 (2009), s. 1822-1832
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	Claviceps purpurea ; Ergot fungus ; Ergot alkaloid gene cluster
Subject RIV	EE - Microbiology, Virology
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000272730000020
DOI	10.1016/j.phytochem.2009.05.023
Annotation	Ergot alkaloids and their derivatives have been traditionally used as therapeutic agents in migraine, blood pressure regulation and help in childbirth and abortion. Their production in submerse culture is a long established biotechnological process. Ergot alkaloids are produced mainly by members of the genus Claviceps, with Claviceps purpurea as best investigated species concerning the biochemistry of ergot alkaloid synthesis (EAS). Genes encoding enzymes involved in EAS have been shown to be clustered; functional analyses of EAS cluster genes have allowed to assign specific functions to several gene products. Various Claviceps species differ with respect to their host specificity and their alkaloid content; comparison of the ergot alkaloid clusters in these species (and of clavine alkaloid clusters in other genera) yields interesting insights into the evolution of cluster structure
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2010

Number of the records: 1