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The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine
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SYSNO ASEP 0334401 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine Author(s) Křížková, J. (CZ)
Burdová, K. (CZ)
Stiborová, M. (CZ)
Křen, Vladimír (MBU-M) RID, ORCID
Hodek, P. (CZ)Source Title Interdisciplinary Toxicology - ISSN 1337-6853
Roč. 2, č. 3 (2009), s. 201-204Number of pages 4 s. Language eng - English Country SK - Slovakia Keywords flavonoids ; cytochrome p450 ; small intestine Subject RIV EE - Microbiology, Virology R&D Projects GD305/09/H008 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) DOI 10.2478/v10102-009-0018-y Annotation Flavonoids, as foreign compounds (xenobiotics), have great potential to modulate the activity of cytochrome P450s (CYPs), xenobiotic-metabolizing enzymes involved in the activation and detoxification of food and environmental carcinogens. Thus, the aim of this study was to investigate the effects of model glycosylated and deglycosylated flavonoids on CYPs in rat liver and small intestine, as the two main organs responsible for xenobiotic metabolism, after p.o. administration by gastric gavages. The effects of two glycosylated flavonoids (isoquercitrin, rutin) and their aglycone (quercetin) on CYPs were determined using Western blotting technique and specific activity assays with alkyl-resorufin derivatives. In liver microsomes, a considerable increase of all the measured marker activities (EROD, MROD, PROD) was observed only after isoquercitrin treatment. Obtained data demonstrate the different effects of flavonoid glycosides and aglycone on CYP expression in rat liver and small intestine Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
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