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NMR structure of the N-terminal domain of capsid protein from the Mason-Pfizer monkey virus

SYSNO ASEP	0334395
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	NMR structure of the N-terminal domain of capsid protein from the Mason-Pfizer monkey virus
Author(s)	Macek, Pavel (MBU-M) Chmelík, Josef (MBU-M)_{RID, ORCID} Křížová, Ivana (UOCHB-X)_RID Kadeřávek, P. (CZ) Padrta, P. (CZ) Žídek, L. (CZ) Wildová, Marcela (UOCHB-X) Hadravová, Romana (UOCHB-X)_{RID, ORCID} Chaloupková, R. (CZ) Pichová, Iva (UOCHB-X)_{RID, ORCID} Ruml, T. (CZ) Rumlová, Michaela (UOCHB-X)_RID Sklenář, V. (CZ)
Number of authors	13
Source Title	Journal of Molecular Biology. - : Elsevier - ISSN 0022-2836 Roč. 392, č. 1 (2009), s. 100-114
Number of pages	15 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	M-PMV ; betaretroviruses ; capsid protein ; NMR structure ; internal dynamics
Subject RIV	CE - Biochemistry
R&D Projects	LC545 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA204/09/1388 GA ČR - Czech Science Foundation (CSF)
	GESCO/06/E001 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000270123600008
DOI	10.1016/j.jmb.2009.06.029
Annotation	The high-resolution structure of the N-terminal domain of the retroviral capsid protein of Mason-Pfizer monkey virus has been determined by NMR. The structure is characterized by a six alpha-helices and an N-terminal beta-hairpin, stabilized by an interaction of Pro1 and Asp57. NMR data obtained for two mutants where beta-hairpin stabilization was disrupted (P1NTDCA and D57ANTDCA) were compared with those for the wild-type. Observed structural changes were supported by biochemical studies.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2010

Number of the records: 1