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Supplementation of Creatine in Sportsman with Hyperhomocysteinemia
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SYSNO ASEP 0334284 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Supplementation of Creatine in Sportsman with Hyperhomocysteinemia Title Suplementace kreatinu u sportovce s hyperhomocysteinemií Author(s) Kohlíková, E. (CZ)
Petr, M. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Přistoupilová, K. (CZ)
Přistoupil, T. I. (CZ)
Pelclová, D. (CZ)
Žák, J. (CZ)
Heyrovský, Michael (UFCH-W) RIDSource Title Atherosklerosa 2009, Diagnostika, léčba, prevence v dětském i dospělém věku. - Praha : IV. interní klinika 1. LF UK Praha, 2009 / Tvrznická E. - ISBN 978-80-254-5389-6 Pages s. 23-26 Number of pages 4 s. Action Atherosklerosa 2009 Event date 09.09.2009-11.09.2009 VEvent location Praha Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords creatine (CR) ; creatinine ; folates ; homocysteine Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GA203/07/1195 GA ČR - Czech Science Foundation (CSF) IAA400400806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40400503 - UFCH-W (2005-2011) Annotation One month's administration of creatine (CR) in the dose of 5 g/day to 11 young active sportsmen affected their daily amount of CR and creatinine excreted into urine. The probands were divided into 4 groups, according to the amount of CR found in urine, and of folates and of vitamin B12 determined in blood. The ganges of folates and vitamin B12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B12, in different metabolic pathways. In 10 men the CR administration was accompanied by an increase of HoCySH level in blood, while for the last man, with accidentally discovered hyperhomocysteinemia, after the month's CR administration the HoCySH level dropped by 50 %. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2010
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