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Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs
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SYSNO ASEP 0334274 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs Title Mnohočetné poruchy v negativní regulaci signální dráhy PKB/Akt zcitlivují lidské nádorové buňky k antiproliferačním účinku nesteroidních antiflogistik Author(s) Lincová, Eva (BFU-R)
Hampl, Aleš (UEM-P)
Pernicová, Zuzana (BFU-R) RID
Staršíchová, Andrea (BFU-R)
Krčmář, P. (CZ)
Machala, M. (CZ)
Kozubík, Alois (BFU-R) RID, ORCID
Souček, Karel (BFU-R) RID, ORCIDNumber of authors 8 Source Title Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 78, č. 6 (2009), s. 561-572Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords PKB/Akt signaling pathway ; NSAIDs ; prostate cancer Subject RIV BO - Biophysics R&D Projects GA204/07/0834 GA ČR - Czech Science Foundation (CSF) GA301/07/1557 GA ČR - Czech Science Foundation (CSF) 1QS500040507 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000268877400003 DOI 10.1016/j.bcp.2009.05.001 Annotation The PKB/Akt signaling pathway, frequently hyperactivated in human cancer, is negatively regulated by PTEN and SHIP2 phosphatases. Human cancer cell lines lacking both of these negative regulators are substantially more sensitive to antiproliferative effect of non-steroidal anti-inflammatory drugs. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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