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Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti

SYSNO ASEP	0334103
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Specificity of anti-saliva immune response in mice repeatedly bitten by Phlebotomus sergenti
Author(s)	Drahota, J. (CZ) Lipoldová, Marie (UMG-J)_RID Volf, P. (CZ) Rohoušová, Iva (UMG-J)
Number of authors	4
Source Title	Parasite immunology. - : Wiley - ISSN 0141-9838 Roč. 31, č. 12 (2009), s. 766-770
Number of pages	5 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	anti-saliva IgG ; cellular response ; Phlebotomus sergenti
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000271469600005
DOI	10.1111/j.1365-3024.2009.01155.x
Annotation	Sand flies transmit parasites of genus Leishmania, the causative agents of leishmaniases. Experimental hosts repeatedly exposed to sand fly saliva can control Leishmania infection. Cell-mediated anti-saliva immune response is most likely responsible for this protective effect; however, there is no study concerning its antigenic specificity. In this study, splenocytes from mice exposed to Phlebotomus sergenti bites were challenged ex vivo with saliva from three different sand flies. Mice bitten by P. sergenti had higher proliferation to homologous antigen than splenocytes from naive mice. Splenocytes from P. sergenti bitten mice as well as anti-P. sergenti antibodies partially cross-reacted with P. papatasi saliva. In contrast, no crossreactivity was found with P. arabicus saliva. Our data indicate that both cellular and humoral immunity react in a species-specific manner and the unique transmission-blocking vaccine would be required for each vector – Leishmania combination.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2010

Number of the records: 1