Number of the records: 1
DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism
- 1.
SYSNO ASEP 0334067 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism Author(s) Zíková, Martina (UMG-J) RID
Corlett, Alicia (UMG-J)
Bendová, Zdeňka (FGU-C)
Pajer, Petr (UMG-J)
Bartůněk, Petr (UMG-J) RIDNumber of authors 5 Source Title Molecular Endocrinology - ISSN 0888-8809
Roč. 23, č. 4 (2009), s. 520-528Number of pages 9 s. Language eng - English Country US - United States Keywords thyroid hormone receptor ; cholesterol metabolism ; sterol-sensing domain Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500520705 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000264707000010 DOI 10.1210/me.2008-0271 Annotation In the body the brain is the most cholesterol-rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol homeostasis. Thyroid hormone receptors, activated in response to thyroid hormone (T3), are known to modulate the level of serum cholesterol via complex regulatory pathways. By screening for T3-regulated genes we identified Disp3, a sterol-sensing protein that is related to the Dispatched family of proteins. Using the model of hyperthyroidism in vivo we observed modulation of the Disp3 expression. DISP3 localizes within the endoplasmic reticulum and was further found to co-localize with cholesterol. Ectopic expression of DISP3 resulted in elevated cholesterol levels combined with an altered cholesterol distribution. Taken together, we propose that DISP3 represents a new molecular link between thyroid hormone and cholesterol metabolism in the brain. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2010
Number of the records: 1