Number of the records: 1
Signalling activated by the death receptors of the TNRF family
- 1.
SYSNO ASEP 0333976 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Signalling activated by the death receptors of the TNRF family Author(s) Anděra, Ladislav (UMG-J) RID Number of authors 1 Source Title Biomedical Papers. - : Univerzita Palackého v Olomouci - ISSN 1213-8118
Roč. 153, č. 3 (2009), s. 173-180Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords death receptors ; apoptosis ; signaling Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000270808400001 Annotation Among the most prominent players in the field of the extracellular signals leading to cell death, preferentially through induction of apoptosis belong several receptors from so-called Death Receptors group of the Tumour Necrosis Factors Receptors (TNFR) family. Over 15 years of the research on activation and regulation of the most prominent member of this group – receptors for the ligands TRAIL, FasL and TNFa brought not only a detail (and still refining) mechanism of these receptors activation and downstream signaling, but also connected them with the ultimate apoptotic gatekeeper – mitochondria. However, in addition to the pro-death signaling, these receptors were also shown under certain circumstances to activate an opposite, pro-proliferative signaling as well as to participate in pro-inflammatory responses. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2010
Number of the records: 1