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CpG methylation controls reactivation of HIV from latency
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SYSNO ASEP 0333948 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title CpG methylation controls reactivation of HIV from latency Author(s) Blažková, Jana (UMG-J)
Trejbalová, Kateřina (UMG-J) RID
Gondois-Rey, F. (FR)
Halfon, P. (FR)
Philibert, P. (FR)
Guiguen, A. (BE)
Verdin, E. (US)
Olive, D. (FR)
Van Lint, C. (BE)
Hejnar, Jiří (UMG-J) RID
Hirsch, I. (FR)Source Title PLoS Pathogens. - : Public Library of Science - ISSN 1553-7366
Roč. 5, č. 8 (2009), e1000554-e1000554Number of pages 14 s. Language eng - English Country US - United States Keywords HIV-1 ; proviral latency ; CpG methylation ; histone modifications ; HAART ; epigenetics Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/05/0939 GA ČR - Czech Science Foundation (CSF) GP204/08/P616 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000270804500010 DOI 10.1371/journal.ppat.1000554 Annotation HIV-1 latency is the main obstacle to the eradication of the virus from infected patients. CpG methylation is known to contribute to transcriptional silencing in general, its role in HIV-1 latency, however, has not been clearly demonstrated and has never been studied in HIV-1-infected patients. We found in an in vitro model and in HIV-1-infected patients that CpG methylation of the HIV-1 promoter is important for the maintenance but not for the establishment of HIV-1 latency. That tight control of HIV-1 latency by CpG methylation could be a key barrier to purging the reservoir of latently infected cells in infected individuals. Our study shows that addition of some histone deacetylase and methyltransferase inhibitors (namely SAHA) reactivate latent HIV and could represent an important part of HAART protocols in the future. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2010
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