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Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics
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SYSNO ASEP 0333811 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics Author(s) Růžičková, Jana (UMG-J)
Piatigorsky, J. (US)
Kozmik, Zbyněk (UMG-J) RIDNumber of authors 3 Source Title International Journal of Developmental Biology. - : Universidad del Pais Vasco - ISSN 0214-6282
Roč. 53, č. 4 (2009), s. 469-482Number of pages 13 s. Language eng - English Country ES - Spain Keywords Eye ; Pax ; lens Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500520908 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA204/08/1618 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000268472800003 DOI 10.1387/ijdb.082793jr Annotation Pax transcription factors are evolutionarily conserved regulators of eye development and can be distinguished on the basis of three functional domains: two DNA-binding domains (the paired domain and the paired-type homeodomain), and the octapeptide motif. PaxB of the eyed cubozoan jellyfish, Tripedalia cystophora, is characterized by a Pax2-like paired domain and octapeptide, and a Pax6-like homeodomain. In mice, functionally distinct Pax6 and Pax2 proteins have unique as well as redundant roles in eye morphogenesis. Here, we show that expression of the jellyfish PaxB gene in mouse embryonic eye tissues impairs normal development of lens and retina. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2010
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