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Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice

SYSNO ASEP	0333492
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice
Author(s)	Železná, Blanka (UOCHB-X)_{RID, ORCID} Maixnerová, Jana (UOCHB-X) Matyšková, Resha (UOCHB-X) Haugvicová, Renata (MBU-M) Blokešová, Darja (UOCHB-X) Maletínská, Lenka (UOCHB-X)_{RID, ORCID}
Number of authors	6
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 58, č. 5 (2009), s. 717-723
Number of pages	7 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	monosodium glutamate (MSG) obesity ; neuropeptide Y (NPY) ; cholecystokinin
Subject RIV	CC - Organic Chemistry
R&D Projects	GA303/05/0614 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
	AV0Z5020903 - MBU-M
UT WOS	000272080200013
Annotation	Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity. The MSG obese mice do not respond to fasting by an increased food intake which makes difficult to measure the effect of peptides attenuating food intake such as cholecystokinin (CCK) or cocaine- and amphetamine-regulated transcript (CART) peptide. However, orexigenic effect of NPY is preserved in the fed MSG obese rodents. In this study with fed lean and MSG obese C57BL/6 male mice, short-term food intake was measured after simultaneous central administration of orexigenic NPY with either CART peptide or peripherally administered CCK. Anorexigenic action of exogenous CART peptide was preserved in MSG obese mice. On the other hand, satiety effect of exogenous CCK was completely lost in MSG obese mice probably because of ineffective leptin signaling in ARC.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2010

Number of the records: 1