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Sensitization, Epileptic-Like Symptoms and Local Synchronization in Patients with Paranoid Schizophrenia
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SYSNO ASEP 0333461 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sensitization, Epileptic-Like Symptoms and Local Synchronization in Patients with Paranoid Schizophrenia Title Sensitizace, epileptické symptomy a lokální synchronizace v EEG pacientů s paranoidní schizofrenií Author(s) Bob, P. (CZ)
Paluš, Milan (UIVT-O) RID, SAI, ORCID
Šusta, M. (CZ)
Glaslová, K. (CZ)Source Title Progress in Neuro-Psychopharmacology & Biological Psychiatry. - : Elsevier - ISSN 0278-5846
Roč. 34, č. 1 (2010), s. 143-146Number of pages 4 s. Language eng - English Country US - United States Keywords coarse-grained information rate ; EEG ; limbic irritability ; schizophrenia ; synchronization Subject RIV FH - Neurology CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000274563400024 EID SCOPUS 73649147680 DOI 10.1016/j.pnpbp.2009.10.015 Annotation Recent findings indicate that changes in synchronization of neural activities underlying sensitization and kindling could be more comprehensively understood using nonlinear methods. With this aim we have examined local synchronization using novel measure of coarse-grained information rate (CIR) in 8 EEG signals recorded at different cortical areas in 44 patients with paranoid schizophrenia. The values of local synchronization that could reflect sensitization related changes in EEG activities of cortical sites were found significantly correlated with psychometric measures of epileptic-like symptoms (LSCL-33) in 7 (of 8) EEG channels (r in the range from 0.307 to 0.374, p<0.05). Results of this study provide first supportive evidence for the relationship between local synchronization measured by CIR and epileptic-like symptoms in schizophrenia. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2010
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