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Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
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SYSNO ASEP 0333023 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III Author(s) Hlouchová, Klára (UOCHB-X) ORCID
Bařinka, C. (US)
Konvalinka, Jan (UOCHB-X) RID, ORCID
Lubkowski, J. (US)Number of authors 4 Source Title FEBS Journal - ISSN 1742-464X
Roč. 276, č. 16 (2009), s. 4448-4462Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords GCPIII ; NAALADase II ; metallopeptidase Subject RIV CE - Biochemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000268466600016 DOI 10.1111/j.1742-4658.2009.07152.x Annotation The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and in the occupancy of the co-catalytic zinc sites. The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2010
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