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Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I)
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SYSNO ASEP 0332891 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I) Author(s) Dračínský, Martin (UOCHB-X) RID, ORCID
Cvačka, Josef (UOCHB-X) RID, ORCID
Semanská, M. (CZ)
Martínek, V. (CZ)
Frei, E. (DE)
Stiborová, M. (CZ)Number of authors 6 Source Title Chemical Research in Toxicology - ISSN 0893-228X
Roč. 22, č. 11 (2009), s. 1765-1773Number of pages 9 s. Language eng - English Country US - United States Keywords Sudan I ; peroxidase ; NMR spectroscopy ; (deoxy)guanosin adducts Subject RIV CE - Biochemistry R&D Projects KJB400550903 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000271654100003 DOI 10.1021/tx900201q Annotation We investigated peroxidase-mediated oxidation of and (deoxy)guanosine adduct formation by 1-phenylazo-2-hydroxynaphthalene (Sudan I), a liver and urinary bladder carcinogen for rodents. Using TLC and/or HPLC combined with mass and/or NMR spectrometry, we characterized the structures of two major peroxidase-mediated Sudan I metabolites and those of adducts of (deoxy)guanosine that are formed during Sudan I oxidation. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2010
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