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Emerging Role of Interleukin-1 in Cardiovascular Diseases
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SYSNO ASEP 0332848 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Emerging Role of Interleukin-1 in Cardiovascular Diseases Title Vliv interleukinu 1 na rozvoj kardiovaskulárních chorob Author(s) Vicenová, B. (CZ)
Vopálenský, D. (CZ)
Burýšek, L. (CZ)
Pospíšek, Martin (UIVT-O)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 58, č. 4 (2009), s. 481-498Number of pages 18 s. Language eng - English Country CZ - Czech Republic Keywords interleukin-1 ; interleukin-1 receptor antagonist protein ; signal pathways ; cardiovascular diseases Subject RIV ED - Physiology R&D Projects 1M06014 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) UT WOS 000270857000003 EID SCOPUS 72549112272 DOI 10.33549/physiolres.931673 Annotation There is an increasing evidence linking dysbalance between various proinflammatory mediators and higher risk of cardiovascular events and pathologies. Likewise, some of the cardiovascular diseases lately appeared to have an autoimmune component. Interleukin-1 (IL-1), a master regulator of diverse inflammatory processes in higher eukaryotes and the key player in numerous autoimmune disorders including rheumatoid arthritis, diabetes mellitus or systemic sclerosis, has recently been proved to be involved in development of several cardiovascular diseases as well. This report aims to give a summary on current knowledge about the IL-1 signaling pathways and about the implication of IL-1 and the IL-1 receptor antagonist (IL-1Ra) in some of the diseases of the cardiovascular system Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2010
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