Number of the records: 1

Constant current chronopotentiometry in detection of changes in protein structures

SYSNO ASEP	0332682
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	Constant current chronopotentiometry in detection of changes in protein structures
Title	Chronopotenciometrie s konstantním proudem při detekci změn v proteinové struktuře
Author(s)	Ostatná, Veronika (BFU-R)_{RID, ORCID} Paleček, Emil (BFU-R)_{RID, ORCID}
Number of authors	2
Source Title	Abstract. - Beijing, 2009 S. 1
Number of pages	1 s.
Action	The 60th Annual Meeting of the International Society of Electrochemistry
Event date	16.08.2009-21.08.2009
VEvent location	Beijing
Country	CN - China
Event type	WRD
Language	eng - English
Country	CN - China
Keywords	protein structure ; constant current chronopotentiometry ; peak H
Subject RIV	BO - Biophysics
R&D Projects	KAN400310651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	KJB100040901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA301/07/0490 GA ČR - Czech Science Foundation (CSF)
	GP202/07/P497 GA ČR - Czech Science Foundation (CSF)
	LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
Annotation	Using the constant current chronopotentiometric stripping analysis (CPSA) and hanging mercury drop or solid amalgam electrodes a well-developed peak (peak H) is produced by practivally all proteins at nanomolar concentrations. Our recent results showed that bare and chemically modified electrodes are particularly useful for recognition of changes in protein structures induced by denaturing, reducing and oxidizing agents as well as by single amino acid exchange in proteins important in cancer. Aggregation of amyloidogenic proteins can also be traced.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1