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Applications of MALDI-TOF MS to large-scale human mtDNA population-based studies
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SYSNO ASEP 0332627 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Applications of MALDI-TOF MS to large-scale human mtDNA population-based studies Title Aplikace MALDI-TOF MS na populačně založené studie velkého rozsahu Author(s) Cerezo, M. (ES)
Černý, Viktor (ARU-G) RID, SAI, ORCID
Carracedo, Á. (ES)
Salas, A. (ES)Number of authors 4 Source Title Electrophoresis. - : Wiley - ISSN 0173-0835
Roč. 30, č. 21 (2009), s. 3665-3673Number of pages 9 s. Publication form www - www Language eng - English Country DE - Germany Keywords Haplogroup ; High-throughput SNP genotyping ; MALDI-TOF MS ; Mitochondrial DNA ; Multiplex assay Subject RIV AC - Archeology, Anthropology, Ethnology R&D Projects GA206/08/1587 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z80020508 - ARU-G (2005-2011) UT WOS 000272126000003 EID SCOPUS 70649088117 DOI 10.1002/elps.200900294 Annotation The article shows how it is possible to analyze mitochondrial DNA coding region SNP variation by MALDI-TOF MS technique. As the African phylogeny has been chosen SNP selection thus aimed to fully cover all the mtSNPs defining major and minor branches of the known African tree, including, macrohaplogroup L, and haplogroups M1, and U6. A total of 230 mtSNPs were finally selected; this number could be lower for the samples from other continents. Test samples collected from two different African locations were used, namely, Mozambique and Chad Basin. The advantages of the MALDI-TOF MS are discussed in comparison with other popular methods. Workplace Institute of Archaeology (Prague) Contact Lada Šlesingerová, slesingerova@arup.cas.cz, Tel.: 257 014 412 Year of Publishing 2010
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